Penicillin concentrations in the cerebrospinal fluid after benzathine penicillin and probenecid in the treatment of syphilis.
نویسندگان
چکیده
منابع مشابه
Cerebrospinal fluid findings after treatment of early syphilis with penicillin.
It has been the practice at the Central VD Clinic, Colombo, to examine the cerebrospinal fluid (CSF) as a test of cure not less than 2 years after treatment for early syphilis. A total of 151 CSF examinations were performed between September, 1963, and August, 1964, in male patients who had been treated for primary or secondary syphilis. The examination was made within 1 hour of lumbar puncture...
متن کاملPenicillin concentrations in serum and cerebrospinal fluid after intramuscular injection of aqueous procaine penicillin 0.6 MU with and without probenecid.
Paired specimens of cerebrospinal fluid and serum were taken from 21 patients to estimate penicillin concentrations two to three hours after the last dose of a course of 14-21 daily intramuscular injections of procaine penicillin 0.6 MU. Of 10 patients treated with procaine penicillin alone, eight had no detectable penicillin and two had sub-treponemicidal concentrations (less than 0.018 mg/l) ...
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Two patients developed neurosyphilis after treatment of latent syphilis with intramuscular benzathine penicillin. The cases confirm recent investigations that show that neither benzathine penicillin nor procaine penicillin in the standard doses results in treponemicidal concentrations of penicillin in cerebrospinal fluid. Neurosyphilis can be treated effectively by intravenous benzylpenicillin ...
متن کاملPenicillin concentrations in cerebrospinal fluid after different treatment regimens for syphilis.
The concentrations of penicillin in the cerebrospinal fluid (CSF) were compared simultaneously with those in the serum in 17 patients with syphilis. The antibiotic concentrations were measured by the agar well diffusion method. There were no detectable concentrations of penicillin in the CSF after administration of benzathine penicillin 2.4 megaunits, benzathine penicillin 7.2 megaunits, procai...
متن کاملNicolau Syndrome after Intramuscular Benzathine Penicillin Injection
A 3-year-old boy was admitted to the emergency department with right lower limb pain, edema, and livedoid discoloration that occurred immediately after intramuscular injection of benzathine penicillin. The patient was diagnosed with Nicolau syndrome, a rare complication of intramuscular injection presumed to be related to the inadvertent intravascular injection. It was first reported following ...
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ژورنال
عنوان ژورنال: Sexually Transmitted Infections
سال: 1982
ISSN: 1368-4973
DOI: 10.1136/sti.58.5.342